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Charity proud for macHypomagnesemia is associated with hypocalcemia, hypokalemia, long-term hyperalimentation, intravenous therapy, diabetes mellitus (especially during treatment of ketoacidosis) alcoholism and other types of malnutrition malabsorption hyperparathyroidism dialysis pregnancy and hyperaldosteronism. It may cause weakness, tremors, tetany, and convulsions. Magnesium deficiency produces neuromuscular disorders. It is also necessary for neuromuscular irritability and blood clotting. Patients taking these drugs should have their magnesium checked approximately once every six months. There is evidence that magnesium may cause arrhythmias.Utilization of certain cardiac drugs which cause adverse effects in the presence of low magnesium (i.e., quinidine, procainamide, and disopyramide phosphate or Norpace). Magnesium deficiency is described with cardiac arrhythmias. Hypomagnesemia may also be induced by amphotericin or anti-EGFR (some monoclonal antibodies) toxicity. Renal loss of magnesium occurs with cis-platinum therapy. These patients should be followed on an as needed basis according to their symptomatology. Chronic alcoholism, diabetic acidosis, and renal tubular acidosis. The frequency should depend on the severity of the syndrome, but once the patient's level is stabilized, a monthly check should be adequate. Patients on long term parenteral nutrition that are otherwise asymptomatic should have their serum magnesium checked monthly. Patients receiving IV magnesium therapy for a low serum level. These patients should have a magnesium check every two to three weeks. Prolonged nasogastric suction greater than five days. Chronic diarrhea, otherwise unexplained and persistent. ![]() Long Q-T syndrome, torsades de pointes and ventricular arrhythmias. Evidence (mixed) that magnesium levels are low and increased magnesium may benefit patients with sickle cell anemia, beta thalassemia and hypersplenism– more recent articles dispute this. Patients receiving oral magnesium in the face of impaired renal function should have their magnesium level checked on a monthly basis. Magnesium: an update on physiological, clinical, and analytical aspects. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. - Am J Emerg Med - 0 21(5): 444-7 Stalnikowicz R - The significance of routine serum magnesium determination in the ED. Goldman: Cecil Textbook of Medicine, 22nd ed., Copyright © 2004 W. Cisplatin and hypomagnesemia. Cardiology 1994 84 Suppl 2:48-56 Metabolic effects of diuretics. Ramsay LE, Yeo WW, Jackson PR. Paolisso G, Scheen A, D'Onofrio F, Lefebvre P. Arch Intern Med 1996 156:1143-8 A review of clinical implications. Hypomagnesemia and diabetes mellitus. Relationship of serum and dietary magnesium to incident hypertension: the Atherosclerosis Risk in Communities (ARIC) Study. Peacock JM, Folsom AR, Arnett DK, Eckfeldt JH, Szklo M. Arch Intern Med 1999 159:285-93 Effects of dietary patterns on blood pressure: Subgroup analysis of the Dietary Approaches to Stop Hypertension (DASH) randomized clinical trial. Svetkey LP, Simons-Morton D, Vollmer WM, Appel LJ, Conlin PR, Ryan DH, Ard J, Kennedy BM. Diabetologia 1990 33:511-4 A review of the sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Schwartz GL and Sheps SG. Arch Intern Med 1997 157:2413-46 The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute. Diabetes Care 1999 22:542-5, Nutrition recommendations and principles for people with diabetes mellitus. American Diabetes Association. Am Fam Physician 1998 58:1323-30 Treatment of hypertension: Insights from the JNC-VI report. 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